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Research Group on Drug Absorption.

 Link to Red Alfa iii Project 

Pharmacy and Pharmaceutical Technology section. School of Pharmacy. UMH

English / Spanish

News and Links of interest


Group Research and personal contributions

Research Report


Research Students

Teaching activities



Descripción: Descripción: Descripción: mbermejo@umh

The research group has a deep expertise on in situ and in vivo animal studies with more than 20 years of experience and has shown a fruitful teaching capacity through more than 20 Ph.D. thesis and dissertations during the last ten years. Now we are working on the development of in vitro models to predict drug absorption and membrane transport in other biological barriers as Blood-Brain-Barrier and skin. We are interested in the validation of these models as tools for bioavailability predictions in humans and in their molecular characterization to go deeply into the mechanism of membrane transport. The group is interested in establishing collaborative research projects with other groups and pharmaceutical companies involved in drug development.

As a group from a Pharmaceutics Department we offer not only experience in pharmacokinetics and biopharmaceutics but also in all the technological aspects of drug formulation and manufacturing.


Group Members:

Descripción: Descripción: Descripción: Marival Bermejo Sanz. Group coordinator.

Marival Bermejo: is currently Professor of Pharmaceutics at the Universidad Miguel Hernández de Elche (Alicante, Spain). She earned her B.Pharm and Ph.D degrees at the same University under the supervision of Prof. Plá-Delfina with a grant from Spanish Government. She got a position as Assistant Professor in 1993 and was promoted to Associate Professor in 1998. In 2008 she was appointed by Universidad Miguel Hernandez to consolidate the Section of Pharmacy in the Department of Engineering and in 2010 she was promoted to her actual position. She performed two research stages at the “Institute of Topology and System Dynamics” in Paris VII University, collaborating with Prof. Christiane Mercier and at the University of Michigan, working with Prof. Gordon Amidon. Dr. Bermejo research was centered on biophysical absorption models and their use in the study of the influence of surfactants on intestinal absorption. Her scientific interest now is centered on drug gastrointestinal absorption and the prediction of oral bioavailability with animal and in vitro models. She is also interested in the study of the influence of membrane efflux transporters in drug ADME properties and in the development of cancer resistance to chemotherapy. Marival Bermejo is member of the “BIOSIM Network of Excellence” and she is the coordinator of the STREP project “MEMTRANS”, both funded by the European Commission and devoted to the improvement of in vitro methods for drug absorption predictions and the use of modeling and simulation as tools in drug development. She has been co-author of forty papers, five of them in Spanish journals, five books chapters. Marival is co-author with Prof. Gordon Amidon (University of Michigan) of Modern Biopharmaceutics (a cd-rom based teaching tool). She is member of the board of directors of the Drug Delivery Foundation. In 2001 her team was awarded with the Research Prize of “Liconsa-Chemo Ibérica” for their work on fluoroquinolones absorption. She is external assessor of the Spanish Agency of Medicines (AGEMED) and EMEA (European Medicines Agency). Prof. Bermejo is Vice-President of the Spanish Society of Pharmaceutics and Pharmaceutical Technology (SEFIG) and EUFEPS


Assistant Prof. Isabel González-Alvarez

Assistant Prof. Marta González-Alvarez

Assistant Prof. Elsa Lopez Pintor


Ph.D Students




Victor Mangas Sanjuán




Victor Mangas is a Ph. D. student under the supervision of Marival Bermejo, Isabel Gonzalez and Marta Gonzalez. He graduated in Pharmacy in 2009 at the Miguel Hernández University and moved to University of Valencia to get the Master degree in Pharmacy. In 2007 received an Erasmus grant at the Philipps University in Marburg (Germany) to continue his Pharmacy degree. Victor Mangas received in 2010 the award “Alumno 5 Estrellas” by the Miguel Hernandez University for his academic merits, personal positive attitude and initiative character.

He has acquired experience in in situ and in vivo techniques in rats and in HPLC analysis and now is working with cell culture in vitro methods to predict intestinal permeability and blood brain barrier penetration. He is also learning PK-PD analysis and becoming competent in the use of modeling and statistical tools as NONMEM, SPSS, S+ and Excel

Victor is interested in doing research stages with groups working in drug absorption and development to improve his knowledge in pharmacokinetics and biopharmaceutical sciences. He is fluent in German and English.



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