Research Group on Drug Absorption. |
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Link to Red Alfa iii
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Pharmacy and Pharmaceutical Technology section. School of Pharmacy. UMH |
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English / Spanish Mission
Group Research and personal contributions
Competence
Projects
Research Report
Facilities
Team
Professors
Research Students
Staff
Teaching activities
Collaborations
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The research group has a deep expertise on in situ and in vivo animal studies with more than 20 years of experience and has shown a fruitful teaching capacity through more than 20 Ph.D. thesis and dissertations during the last ten years. Now we are working on the development of in vitro models to predict drug absorption and membrane transport in other biological barriers as Blood-Brain-Barrier and skin. We are interested in the validation of these models as tools for bioavailability predictions in humans and in their molecular characterization to go deeply into the mechanism of membrane transport. The group is interested in establishing collaborative research projects with other groups and pharmaceutical companies involved in drug development. As a group from a
Pharmaceutics Department we offer not only experience in pharmacokinetics and
biopharmaceutics but also in all the technological
aspects of drug formulation and manufacturing. |
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Group
Members: |
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Prof. Marival Bermejo Sanz. Group coordinator. Marival Bermejo: is currently
Professor of Pharmaceutics at the Universidad Miguel Hernández de Elche
(Alicante, Spain). She earned her B.Pharm and Ph.D degrees at the same University under the supervision
of Prof. Plá-Delfina with a grant from Spanish
Government. She got a position as Assistant Professor in 1993 and was
promoted to Associate Professor in 1998. In 2008 she was appointed by
Universidad Miguel Hernandez to consolidate the Section of Pharmacy in the
Department of Engineering and in 2010 she was promoted to her actual
position. She performed two research stages at the “Institute of Topology and
System Dynamics” in Paris VII University, collaborating with Prof. Christiane
Mercier and at the University of Michigan, working with Prof. Gordon Amidon.
Dr. Bermejo research was centered on biophysical absorption models and their
use in the study of the influence of surfactants on intestinal absorption.
Her scientific interest now is centered on drug gastrointestinal
absorption and the prediction of oral bioavailability with animal
and in vitro models. She is also interested in the study of the influence of membrane
efflux transporters in drug ADME properties and in the development of cancer
resistance to chemotherapy. Marival Bermejo is member of the “BIOSIM
Network of Excellence” and she is the coordinator of the STREP project
“MEMTRANS”, both funded by the European Commission and devoted to the
improvement of in vitro methods for drug absorption predictions and the use
of modeling and simulation as tools in drug development. She has been
co-author of forty papers, five of them in Spanish journals, five books
chapters. Marival is co-author with Prof. Gordon Amidon (University of
Michigan) of Modern Biopharmaceutics (a cd-rom
based teaching tool). She is member of the board of directors of the Drug Delivery Foundation. In 2001
her team was awarded with the Research Prize of “Liconsa-Chemo
Ibérica” for their work on fluoroquinolones
absorption. She is external assessor of the Spanish Agency of Medicines
(AGEMED) and EMEA (European Medicines Agency). Prof. Bermejo is
Vice-President of the Spanish Society of Pharmaceutics and Pharmaceutical
Technology (SEFIG) and EUFEPS |
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Assistant Prof. Elsa Lopez Pintor |
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Ph.D Students |
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Victor
Mangas is a Ph. D. student under the supervision of Marival Bermejo, Isabel
Gonzalez and Marta Gonzalez. He graduated in Pharmacy in 2009 at the Miguel
Hernández University and moved to University of Valencia to get the Master
degree in Pharmacy. In 2007 received an Erasmus grant at the Philipps University in Marburg (Germany) to continue his
Pharmacy degree. Victor Mangas received in 2010 the award “Alumno 5 Estrellas” by the
Miguel Hernandez University for his academic merits, personal positive
attitude and initiative character. He
has acquired experience in in situ
and in vivo techniques in rats and
in HPLC analysis and now is working with cell culture in vitro methods to predict intestinal permeability and blood
brain barrier penetration. He is also learning PK-PD analysis and becoming
competent in the use of modeling and statistical tools as NONMEM, SPSS, S+
and Excel Victor
is interested in doing research stages with groups working in drug absorption
and development to improve his knowledge in pharmacokinetics and
biopharmaceutical sciences. He is fluent in German and English. |
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